A REVIEW ON HISTONE VARIANTS AND THE REGULATION OF GENE EXPRESSION

Abstract

Nucleosome is a structure formed by an octamer of H2A, H2B, H3 and H4 histones around which the DNA is rolled, in some cases histone variants that dramatically change the properties of the nucleosome, as well as its interaction with DNA may, occur. These histone variants, which occur naturally in organisms, are part of epigenetics, which refers to the study of the regulation of gene expression without the alteration of the genomic sequences of the organisms. This review identifies some aspects of historical variants and the unique way in which gene expression is regulated, issues that are currently the subject of numerous research around the world.