DETERMINATION OF PARACETAMOL BY SQUARE WAVE VOLTAMPEROMETRY USING A PLATINUM ELECTRODE
Article Sidebar
Main Article Content
Abstract
The application of square wave voltammetry (SWV for its acronym in English) was studied for the quantification of paracetamol (PAR) using a platinum electrode as a working electrode. The reliability of the method was determined by determining analytical parameters such as the limit detection, limit of quantification and percentage of recovery. The electrochemical behavior of PAR was evaluated from acetate and phosphate buffer solutions, at pH levels between 4 and 6 in a potential range of +0 to +2 V vs Ag/AgCl, at a scanning speed of 50 mVs-1 by cyclic voltammetry (VC). The appearance of the anodic peak of the analyte occurred at a potential of 0.6 V. The analytical parameters were optimized, finding better electrochemical responses at a frequency of 10 Hz with a pulse width of 100 mV and a scan increment of 10 mV. The detection and quantification limits obtained were 0.6 mM and 2.0 mM, respectively. The PAR recovery percentage ranged from 96.97 to 104.54 %. Finally, the application of this technique is a reliable, simple, and fast alternative.
Downloads
Article Details
- The authors agree to respect the academic information of other authors, and to assign the copyrights to the journal infoANALÍTICA, so that the article can be edited, published and distributed.
- The content of the scientific articles and the publications that appear in the journal is the exclusive responsibility of their authors. The distribution of the articles published in the infoANALÍTICA Journal is done under a Creative Commons Reconocimiento-CompartirIgual 4.0 Internacional License.
References
Acevedo-Barrios, R. L., Severiche-Sierra, C. A., & Del Carmen Jaimes Morales, J. (2017). Efectos tóxicos del paracetamol en la salud humana y el ambiente. In Revista de Investigación Agraria y Ambiental, 8(1), 139–149.
Alswayeh, R., Alvi, S. N., & Hammami, M. M. (2016). Rapid determination of acetaminophen levels in human plasma by high performance liquid chromatography. Am J PharmTech Res, 6(3), 710–719.
Camargo, J., Andreotti I., Kalinke C., Henrique J., Bonacin J. & Janegitz B. (2019). Waterproof paper as a new substrate to construct a disposable sensor for the electrochemical determination of paracetamol and melatonin. Talanta. 208, 120458) https://doi.org/10.1016/j.talanta.2019.120458.
Doğan, B., Elik, A., & Altunay, N. (2020). Determination of paracetamol in synthetic urea and pharmaceutical samples by shaker-assisted deep eutectic solvent microextraction and spectrophotometry. In Microchemical Journal, 154, 104-645.
Gholivand, M. & Ahmadi, A. (2019). Anodic Stripping Voltammetric Determination of Paracetamol at Poly Luminol/Functionalized Multi-Walled Carbon Nanotubes Modified Glassy Carbon Electrode. Russian Journal of Electrochemistry, 55(12), 1151–1161).DOI: 10.1134/S102319351912005X
Jiménez, R. (2017). Caracterización del Ácido Gamma-Hidroxibutírico sobre superficies de platino. Universidad de Córdoba: Tesis Doctoral. http://helvia.uco.es/handle/10396/14632
Orellana Jaramillo, A. M. (2018). Validación de una técnica electroanalitica para la determinación de paracetamol en medios acuosos enfocados a la ecofarmacovigilancia [Bioquímica y farmacia, Machala: Universidad Técnica de Machala]. http://repositorio.utmachala.edu.ec/handle/48000/12334
Patil, M. M., Shetti, N. P., Malode, S. J., Nayak, D. S., & Chakklabbi, T. R. (2019). Electroanalysis of paracetamol at nanoclay modified graphite electrode. In Materials Today: Proceedings 18, 986–993. https://doi.org/10.1016/j.matpr.2019.06.538
Phong Vo, H. N., Le, G. K., Hong Nguyen, T. M., Bui, X.-T., Nguyen, K. H., Rene, E. R., Vo, T. D. H., Thanh Cao, N.-D., & Mohan, R. (2019). Acetaminophen micropollutant: Historical and current occurrences, toxicity, removal strategies and transformation pathways in different environments. Chemosphere, 236, 124391.
Radi, A., & El-Sherif, Z. (2002). Determination of levofloxacin in human urine by adsorptive square-wave anodic stripping voltammetry on a glassy carbon electrode. Talanta, 58(2), 319–324.
Rkik, M., Brahim, M. B., & Samet, Y. (2017). Electrochemical determination of levofloxacin antibiotic in biological samples using boron doped diamond electrode. Journal of Electroanalytical Chemistry , 794, 175–181.
Stamboroski, S. (2016). Sensor eletroquímico constituído de nanoplaquetas de grafite dispersas em quitosana para determinação de paracetamol em fármacos. Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Departamento de Química: Tesis.
Wong, A., Santos, A. M., & Fatibello-Filho, O. (2018). Simultaneous determination of paracetamol and levofloxacin using a glassy carbon electrode modified with carbon black, silver nanoparticles and PEDOT:PSS film. In Sensors and Actuators B: Chemical 255, 2264–2273). https://doi.org/10.1016/j.snb.2017.09.020
Zaira, A. C., & Ruiz, M. J. (2016). Ensayos de ecotoxicidad de los fármacos y efectos tóxicos en el medio ambiente: Revisión. Revista de Toxicología. https://www.redalyc.org/pdf/919/91949104007.pdf